Naphthylalkyl lactamimides as inhibitors of blood platelet aggregation

EM Roberts, JM Grisar, RD Mackenzie…

Index: Roberts,E.M. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, # 12 p. 1270 - 1273

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Citation Number: 6

Abstract

Hexahydro-2-[1-(1-naphthyl) ethylimino] azepine. HCl (2)(RMI 7822) was found to inhibit human blood platelet aggregation induced by ADP and other agents with minimal release of procoagulant platelet factor 3. The compound was selected after careful modification of structural parameters, such as a-substitution, lactam ring size, aromatic substitution, as well as evaluation of its optical isomers.

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