Base-catalyzed addition of thiols to α, β-unsaturated anhydrides

FB Zienty, BD Vineyard…

Index: Zienty,F.B. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 3140 - 3146

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Citation Number: 32

Abstract

Reaction of a variety of thiols, including hydrogen sulfide, with a, b-unsaturated cyclic anhydrides in the presence of a basic catalyst under anhydrous conditions produced alkylthio and arplthio anhydrides rapidly and in high yields. The addition of thiols to maleic anhydride afforded a convenient direct method of making dl-alkylthio-and arylthiosuccinic anhydrides; the heretofore inaccessible tert-alkylthiosuccinic acids and anhydrides can be ...