3-Phenylpiperidines. Central dopamine-autoreceptor stimulating activity
U Hacksell, LE Arvidsson, U Svensson…
Index: Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482
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Citation Number: 94
Abstract
Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3- hydroxyphenyl)-Nn-propylpiperidine have been synthesized and tested for central dopamineautoreceptor stimulating activity. The 3-(3-hydroxypheny1) piperidine moiety seems indispensable for high potency and selectivity. Introduction of an additional hydroxyl group into the 4 position of the aromatic ring gives a compound with dopaminergic activity ...
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