Synthesis

Chemistry of Polyhalogenated Nitrobutadienes, Part 7: A Novel Synthetic Access to Chlorinated Nitrile Oxides

E Nutz, VA Zapol'skii, DE Kaufmann

Index: Nutz, Eva; Zapol'Skii, Viktor A.; Kaufmann, Dieter E. Synthesis, 2009 , # 16 p. 2719 - 2724

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Abstract

Abstract Reaction of gem-dichloronitroalkenes with base leads to the formation of chlorinated nitrile oxides, probably via a cyclic intermediate. The 1, 3-dipoles can be trapped with alkenes to give dihydroisoxazoles with a chlorinated side chain in 3-position. This novel synthetic method is fairly general.

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