Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors

D Chianelli, YC Kim, D Lvovskiy, TR Webb

Index: Chianelli, Dona; Kim, Yong-Chul; Lvovskiy, Dmitriy; Webb, Thomas R. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5059 - 5068

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Citation Number: 26

Abstract

Nonpeptide compounds that mimic bioactive peptides are desirable for a number of clinical indications. We report a new practical method for the design of scaffolds exhibiting drug-like properties that are suitable for the display of peptide pharmacophores. The synthesis of various synthons of 7′-hydroxy-2′, 3′-dihydro-1′ H, 2H, 5H-spiro [imidazolidine-4, 4′- quinoline]-2, 5-dione (1) and methods for the introduction of several mimics of amino acid ...