Anti-Influenza Drug Discovery: Structure− Activity Relationship and Mechanistic Insight into Novel Angelicin Derivatives

JY Yeh, MS Coumar, JT Horng, HY Shiao…

Index: Yeh, Jiann-Yih; Coumar, Mohane Selvaraj; Horng, Jim-Tong; Shiao, Hui-Yi; Kuo, Fu-Ming; Lee, Hui-Ling; Chen, In-Chun; Chang, Chun-Wei; Tang, Wen-Fang; Tseng, Sung-Nain; Chen, Chi-Jene; Shih, Shin-Ru; Hsu, John T.-A.; Liao, Chun-Chen; Chao, Yu-Sheng; Hsieh, Hsing-Pang Journal of Medicinal Chemistry, 2010 , vol. 53, # 4 p. 1519 - 1533

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Citation Number: 66

Abstract

By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced cytopathic effect in Madin− Darby canine kidney cell culture in low micromolar range. Detailed structure− activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore B, while meta-substituted phenyl/2-thiophene rings are optimal in pharmacophore A and C. ...