Synthesis and antiviral activity of benzisatin β-oximes

…, EI Boreko, GV Vladyko, LV Korobchenko

Index: Mazhilis, L. I.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 11 p. 924 - 927 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 11 p. 1349 - 1352

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Citation Number: 2

Abstract

For this purpose, benz [e]-and benz [g] isatins [3] were reacted with hydroxylamine and O- methylhydroxylamine, and the resulting oximes were acetylated. The structures of the principal products were confirmed by their PMR spectra (Table 2). Assignment of the signals for the aromatic protons was made by comparison with the previously-synthesized [i, 3, 5, 6] related compounds. It is noteworthy that acetylation of the oxime (IX) with an excess of ...