Tetrahedron: Asymmetry

Asymmetric synthesis of (−)-α-conhydrine

SRV Kandula, P Kumar

Index: Kandula, Subba Rao V.; Kumar, Pradeep Tetrahedron Asymmetry, 2005 , vol. 16, # 19 p. 3268 - 3274

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Citation Number: 30

Abstract

Alkaloid mimics with a nitrogen in the ring, especially those α-substituted by a 1-hydroxyalkyl side chain, constitute a framework frequently encountered in natural alkaloids. 1 This pattern is found in many biologically active alkaloids such as conhydrine 1, (−)-castanospermine 2, (−)-slaframine 3, and (−)-swainsonine 4 (Fig. 1). 2 Conhydrine is one of the alkaloids of the hemlock, isolated from the seeds and leaves of the poisonous alkaloids plant Conium ...