N-Substituted homopiperazine barbiturates as gelatinase inhibitors

J Wang, C Medina, MW Radomski, JF Gilmer

Index: Wang, Jun; Medina, Carlos; Radomski, Marek W.; Gilmer, John F. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4985 - 4999

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Citation Number: 27

Abstract

Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5, 5- Disubstituted barbiturates hold promise as inhibitor types being stable in vivo and relatively selective for the gelatinases (MMP-2 and MMP-9). In this paper we describe the synthesis of 5-piperazine and-homopiperazine substituted barbiturates. The activity of these ...