Novel 5, 5-disubstitutedpyrimidine-2, 4, 6-triones as selective MMP inhibitors
LH Foley, R Palermo, P Dunten, P Wang
Index: Foley, Louise H; Palermo, Robert; Dunten, Pete; Wang, Ping Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 8 p. 969 - 972
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Citation Number: 38
Abstract
The 5, 5-disubstitutedpyrimidine-2, 4, 6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.
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