Synthese ete＇ tudein vitro de l'activite＇ antiagre＇ gante plaquettaire de de＇ rive＇ s de la te＇ trahydro-1, 2, 3, 4 quinazoline

…, JP Dupin, G Hou, M Boisseau, H Bernard

Index: Gravier; Dupin; Casadebaig; Hou; Boisseau; Bernard European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 531 - 535

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Abstract

Abstract Une vingtaine de tetrahydro-1, 2, 3, 4 quinazolines substituees en 3 originales ontetesynthetisees. L'etude in vitro de leur activiteantiagregante plaquettaire vis-a-vis de differents inducteurs de l'agregation plaquettaire (ADP—collagene—acide arachidonique) aeterealisee, ainsi que la mesure de leur pouvoir inhibiteur de la liberation des constituants plaquettaires et de la synthese du throm☐ ane A 2. Toutes ces molecules possedent un ...

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