Copper-catalyzed direct thiolation of xanthines and related heterocycles with disulfides

Z He, F Luo, Y Li, G Zhu

Index: He, Zuying; Luo, Fang; Li, Yinglong; Zhu, Gangguo Tetrahedron Letters, 2013 , vol. 54, # 44 p. 5907 - 5910

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Citation Number: 8

Abstract

Abstract A novel copper-catalyzed, base-free direct thiolation of xanthines and related heterocycles is described, featuring the use of inexpensive Cu (OAc) 2· H 2 O as the catalyst, O 2 as a clean and cheap oxidant, and easy-to-handle disulfides as the thiolation reagents. It works well for both aryl and alkyl disulfides. Moreover, the resultant products can be converted into 8-(hetero) aryl-or alkenyl-substituted xanthines in good yields via the ...