Tetrahedron Letters

Efficient propylphosphonic anhydride (® T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles

X Wen, J El Bakali, R Deprez-Poulain, B Deprez

Index: Wen, Xiaoan; Bakali, Jamal El; Deprez-Poulain, Rebecca; Deprez, Benoit Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2440 - 2443

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Citation Number: 56

Abstract

Propylphosphonic anhydride (® T3P) promotes cyclization of o-aminobenzenethiol, o- aminophenol, and o-phenylenediamine with carboxylic acids under microwave irradiation. The one-pot procedure is efficient and allows short reaction times, easy workup, and good yields. Thus, we describe here a method for quick preparation of benzothiazoles, benzoxazoles and benzimidazoles.

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