Tetrahedron letters

Annovel formamidine linker for use in solid-phase synthesis

PS Furth, MS Reitman, AF Cook

Index: Furth, Paul S.; Reitman, Michael S.; Cook, Alan F. Tetrahedron Letters, 1997 , vol. 38, # 31 p. 5403 - 5406

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Citation Number: 46

Abstract

A variety of amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate α-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic ...