From biomass to medicines. A simple synthesis of indolo [3, 2-c] quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

MG Uchuskin, AS Pilipenko, OV Serdyuk…

Index: Uchuskin, Maxim G.; Pilipenko, Arkady S.; Serdyuk, Olga V.; Trushkov, Igor V.; Butin, Alexander V. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 36 p. 7262 - 7265

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Citation Number: 24

Abstract

Indolo [3, 2-c] quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.

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