New access to oxazolopyridines via hydroxyamidine derivatives; Application to quinolines

E Garnier, S Blanchard, I Rodriguez, C Jarry…

Index: Garnier, Ethel; Blanchard, Stephanie; Rodriguez, Ivan; Jarry, Christian; Leger, Jean-Michel; Caubere, Paul; Guillaumet, Gerald Synthesis, 2003 , # 13 p. 2033 - 2040

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Citation Number: 20

Abstract

Abstract Several 2-aryl and 2-heteroaryloxazolo [4, 5-b] pyridines were synthesised in high yields from zwitterion or hydroxyamidine derivatives by heating in dimethylacetamide. These intermediates were generated via hetarynic reaction with the complex base NaNH 2-t- BuONa (5: 2). The same reactions were possible with quinoline derivatives.