Microwave-assisted synthesis and in-vitro anti-tumor activity of 1, 3, 4-triaryl-5-N-arylpyrazole-carboxamides

HA Abdel-Aziz, HSA El-Zahabi, KM Dawood

Index: Abdel-Aziz, Hatem A.; El-Zahabi, Heba S.A.; Dawood, Kamal M. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2427 - 2432

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Citation Number: 71

Abstract

Regioselective 1, 3-dipolar cycloaddition of nitrilimines with 5-arylidene-2-arylimino-4- thiazolidinones and with 2-(4-arylidene) thiazolo [3, 2-a] benzimidazol-3 (2H)-ones afforded the corresponding 1, 3, 4-triaryl-5-N-arylpyrazole-carboxamides and pyrazolylbenzimidazoles. All reactions were carried out under conventional thermal heating and/or microwave irradiation. Both the pyrazole-5-carboxamides and ...