Synthesis of N??Phenyl??N′??pyrimidylurea Derivatives by Selenium??or Selenium Dioxide??Catalyzed Reductive Carbonylation of Nitroaromatics

J Chen, G Ling, S Lu

Index: Chen, Jinzhu; Ling, Gang; Lu, Shiwei European Journal of Organic Chemistry, 2003 , # 17 p. 3446 - 3452

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Citation Number: 12

Abstract

Abstract Forty unsymmetric N-phenyl-N′-pyrimidylurea derivatives were synthesized in moderate-to-good yields by one-pot reductive carbonylation of nitroaromatics using selenium or selenium dioxide as the catalyst, aminopyrimidine derivatives as co-reagents, and carbon monoxide as the carbonyl source. The reaction parameters were investigated, as was the reusability of the catalysts. We found that selenium-or selenium dioxide- ...