Structure–activity relationships of chalcone analogs as potential inhibitors of ADP-and collagen-induced platelet aggregation

MVB Reddy, WJ Tsai, K Qian, KH Lee, TS Wu

Index: Vijaya Bhaskar Reddy; Tsai, Wei-Jern; Qian, Keduo; Lee, Kuo-Hsiung; Wu, Tian-Shung Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7711 - 7719

Full Text: HTML

Citation Number: 10

Abstract

In an effort to develop potent antiplatelet agents, 12 O-prenylated (2–13) and 10 O-allylated (14–23) chalcones were synthesized and screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by ADP (20μM) and collagen (10μg/mL). In addition, the platelet aggregation activity of previously synthesized Mannich bases of heterocyclic chalcones (MBHC)(24–62) was evaluated. The preliminary structure–activity ...

Related Articles:

Asymmetric Syntheses of the Flavonoid Diels–Alder Natural Products Sanggenons C and O

[Tan, Wenfei; Li, Wei-Dong Z.; Huang, Chusheng; Li, Yulin; Xing, Yacheng Synthetic Communications, 1999 , vol. 29, # 19 p. 3369 - 3377]

Natural products as sources of new fungicides (I): synthesis and antifungal activity of acetophenone derivatives against phytopathogenic fungi

[Ma, Ya-Tuan; Fan, Hua-Fang; Gao, Yu-Qi; Li, He; Zhang, An-Ling; Gao, Jin-Ming Chemical Biology and Drug Design, 2013 , vol. 81, # 4 p. 545 - 552]

More Articles...