Cobalt??Catalyzed Cross??Coupling Reaction between Functionalized Primary and Secondary Alkyl Halides and Aliphatic Grignard Reagents

…, C Chaboche, C Duplais, A Giulliani…

Index: Cahiez, Gerard; Chaboche, Christophe; Duplais, Christophe; Giulliani, Arianna; Moyeux, Alban Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1484 - 1488

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Citation Number: 47

Abstract

Abstract The coupling of primary and secondary unactivated alkyl bromides with alkyl- Grignard reagents was performed in good yields under mild conditions by using a new catalytic system: consisting of cobalt chloride and tetramethylethylenediamine (CoCl 2⋅ 2 LiI, 4 TMEDA). The reaction is very chemoselective since ketone, ester and nitrile functions are tolerated.