An improved procedure for the preparation of 8-substituted guanines

…, F De Giacomo, DE Paterson, TG George…

Index: Xu, Ming; De Giacomo, Fabio; Paterson, Duncan E.; George, Tesmol G.; Vasella, Andrea Chemical Communications, 2003 , # 12 p. 1452 - 1453

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Citation Number: 24

Abstract

The synthesis of purines and purine nucleosides continue to attract medicinal interest 1 due to their antimicrobial properties 2 and their interaction with adenosine receptors. 3 The double condensation of 4,5-diaminopyrimidines with one-carbon electrophiles (Traube synthesis) and related methods 4 remain by far the most important routes for the construction of purines, although closure of the imidazole ring to give C(8)-substituted derivatives is generally more difficult ...