Synthesis and evaluation of different fatty acid esters formulated into Precirol ATO-based lipid nanoparticles as vehicles for topical delivery

V Sanna, A Mariani, G Caria, M Sechi

Index: Sanna, Vanna; Mariani, Alberto; Caria, Giuseppe; Sechi, Mario Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 7 p. 680 - 684

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Citation Number: 12

Abstract

A series of isopropyl fatty esters having different chain length (C 13—C 23) were synthesized and formulated in lipid nanoparticles based on Precirol® ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by high shear homogenization method, had a mean ...