New Synthesis of Aryl and Heteroaryl N??Acylureas via Microwave??Assisted Palladium??Catalysed Carbonylation

D Liptrot, L Alcaraz, B Roberts

Index: Liptrot, David; Alcaraz, Lilian; Roberts, Bryan Advanced Synthesis and Catalysis, 2010 , vol. 352, # 13 p. 2183 - 2188

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Citation Number: 22

Abstract

Abstract A new, practical synthesis of aryl and heteroaryl N-acylureas has been developed via palladium-catalysed carbonylation of aryl or heteroaryl halides in the presence of urea nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation, using either carbon monoxide gas in a vessel equipped with a gas inlet adapter, or molybdenum hexacarbonyl as the carbon monoxide source in ...