Synthesis and Some Reactions of 2-(2-Aminoanilino) cyclohepta [b] pyrroles: Leading to 5H-Cyclohepta [1′, 2′: 4, 5] pyrrolo [2, 3-b][1, 5] benzodiazepine, a Novel …

N Abe, N Ishikawa, T Hayashi, Y Miura

Index: Abe, Noritaka; Ishikawa, Naomi; Hayashi, Takashi; Miura, Yoshiaki Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 6 p. 1617 - 1622

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Citation Number: 10

Abstract

2-Chlorocyclohepta [b] pyrroles reacted with o-phenylenediamine to give 2-(2-aminoanilino) cyclohepta [b] pyrroles (2a, b) in good yields. Treatment of 2a and 2b with polyphosphoric acid afforded cyclohepta [1′, 2′: 4, 5] pyrrolo [1, 2-a] benzimidazole (4a) in good yields. Treatment of 2b with acids gave 6-(ethoxycarbonyl) derivatives (4b) of 4a and 12H-5, 13- dihydrocyclohepta [1′, 2′: 4, 5] pyrrolo [2, 3-b][1, 5] benzodiazepin-12-one (5). ...