Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl) phenyl] acrylate derivatives

RB Chaudhari, SD Vaidya, BK Karale…

Index: Chaudhari, Raju B.; Vaidya, Sanjay D.; Karale; Pawar; Rindhe, Sahebrao S. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 9 p. 1208 - 1215

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Abstract

Abstract: Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl) phenyl] acrylate derivatives has been reported. These derivatives are prepared by condensation of o- phenylenediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1H-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles ...

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