Journal of medicinal chemistry

Chemical Structure and Pharmacological Activity of Glycine Derivatives. Influence of Disubstitution of the Amine Function of Glycine Esters and Hydrazides1a

R Rips, C Derappe, P Magnin

Index: Rips,R. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 529 - 531

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Citation Number: 1

Abstract

The substitution of the amine function of ethyl glycinate by aliphatic or cyclic radicals leads to the formation of compounds of interesting biological activity, in particular, spasmolytic, antihistaminic, and hypotensive activities. Study of the replacement of the ester function by a hydrazide group has been made. Contrary to expectation, the hydrazides are not convulsants.