Tetrahedron

Titanium catalyzed one-pot multicomponent coupling reactions for direct access to substituted pyrimidines

S Majumder, AL Odom

Index: Majumder, Supriyo; Odom, Aaron L. Tetrahedron, 2010 , vol. 66, # 17 p. 3152 - 3158

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Citation Number: 25

Abstract

A titanium-catalyzed 3-component coupling reaction can be used to generate tautomers of 1, 3-diimines. These diimines produced in situ undergo condensation with amidines in a one- pot procedure to provide substituted pyrimidines. Seventeen examples of pyrimidines are provided using this one-pot, 4-component procedure from simple starting materials. In some cases, catalyst architecture can be tuned to control the regioselectivity of the alkyne ...

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