New anticonvulsants: Schiff bases of. gamma.-aminobutyric acid and. gamma.-aminobutyramide

…, P Feltz, PM Headley, P Worms, KG Lloyd…

Index: Kaplan; Raizon; Desarmenien; Feltz; Headley; Worms; Lloyd; Bartholini Journal of Medicinal Chemistry, 1980 , vol. 23, # 6 p. 702 - 704

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Citation Number: 88

Abstract

Under physiological conditions y-aminobutyric acid (YAbu) poorly crosses the blood-brain barrier.'Of the putative yAbu mimetics prepared to date which enter the brain, only muscimol has been widely examined, and even this compound enters the brain to a very limited extent.* However, muscimol exhibits an unacceptable central nervous system toxicity, which prevents its wide clinical US^.^'^ From the pharmacological activities of muscimol and the ...