The Journal of Organic Chemistry

Chemical modification of nucleic acid components: reactions of cytosine, cytidine, isocytosine, and adenine with methyl N-cyanomethanimidate

RS Hosmane, NJ Leonard

Index: Hosmane, Ramachandra S.; Leonard, Nelson J. Journal of Organic Chemistry, 1981 , vol. 46, # 7 p. 1457 - 1465

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Citation Number: 28

Abstract

4H-pyrimido [1, 6-a]-1, 3, 5-triazin-4-ylidene) guanidine (4) and (6, 7-dihydro-6-oxo-4H- pyrimido [1, 6-a]-1, 3, 5-triazin-4-y1idene) guanidine (5), respectively. The interrelationship between the two compounds was established by deribosidation of 4. The reaction of 1 with isocytosine gave two isomeric products (6-oxo-6H-pyrimido-[1, 2-~]-1, 3, 5-triazin-4-yl) guanidine (9) and (8-0~ 0-8H-pyzimido [l, 2-a]-1, 3, 5-triazin-4-yl) guanidine (10). The two ...