Tetrahedron

Polyfunctional (R)-2-hydroxycarboxylic acids by reduction of 2-oxo acids with hydrogen gas or formate and resting cells of Proteus vulgaris

A Schummer, H Yu, H Simon

Index: Schummer, Anita; Yu, Hongtao; Simon, Helmut Tetrahedron, 1991 , vol. 47, # 43 p. 9019 - 9034

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Citation Number: 48

Abstract

Various (R)-2-hydroxy acids such as (R)-2-hydroxy-3-enoic-, 3, 5-dienoic-, 4-oxo-,(R, S)-3- hydroxy and some others were prepared on a scale up to 0.12 mol by biocatalytic reduction of the corresponding 2-oxo acids with P. vulgaris and hydrogen gas and/or formate as electron donors. With the exception of the 2-hydroxy-4-oxo acids it could be proved that the enantiomeric excess is> 97%. For the 4-oxo derivatives this enantiomeric excess can be ...

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