Helvetica chimica acta

Synthesis of 1, 3, 4, 5??Tetrahydro??2??benzoxepin Derivatives as Conformationally Restricted Analogues of cyclamenaldehyde??type compounds and as intermediates …

G Skouroumounis, B Winter

Index: Skouroumounis, Georges; Winter, Beat Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 1095 - 1109

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Citation Number: 11

Abstract

Abstract Nine 1, 3, 4, 5-tetrahydro-2-benzoxepin derivatives have been prepared as mimics of the folded (gauche) conformation of cyclamenaldehyde (1) and related compounds, but none of them showed the typical lily-of-the valley (muguet) odour activity. However, conversion of these substances to previously unknown analogues of 1 having a Me substituent on the aromatic ring in an ortho position to the side chain led to new fragrance ...