Novel potent and selective inhibitors of inducible nitric oxide synthase.
M Nakane, V Klinghofer, JE Kuk, JL Donnelly…
Index: Nakane, Masaki; Klinghofer, Vered; Kuk, Jane E.; Donnelly, Jennifer L.; Budzik, Gerald P.; Pollock, Jennifer S.; Basha, Fatima; Carter, George W. Molecular Pharmacology, 1995 , vol. 47, # 4 p. 831 - 834
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Citation Number: 153
Abstract
Abstract We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5, 6-dihydro-6-methyl-4H-1, 3-thiazine. Ki values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5, 6-dihydro-6-methyl-4H-1, 3- thiazine were obtained with partially purified preparations of inducible nitric oxide synthase. These compounds demonstrate about 1000-fold greater potency than prototypical ...
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