Journal of heterocyclic chemistry

Synthesis of substituted 3??phenyl??6h??pyrazolo [4, 3??d] isoxazoles from corresponding 4??benzoyl??5??hydroxypyrazoles

W Holzer, K Hahn

Index: Holzer, Wolfgang; Hahn, Katharina Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 303 - 308

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Citation Number: 31

Abstract

Abstract Treatment of 1,(3)-(di) substituted 4-benzoyl-5-hydroxypyrazoles with phosphorus oxychloride affords the corresponding 4-benzoyl-5-chloropyrazoles. Reaction of the latter with hydroxylamine leads to oximes, which can be cyclized to novel 3-phenyl-6H-pyrazolo [4, 3-d] isoxazoles by treatment with sodium hydride in dimethyl formamide. Detailed nmr spectroscopic studies (1 H, 13 C) with all obtained compounds are presented.