Design, synthesis and antimycobacterial activity of cinnamide derivatives: a molecular hybridization approach

…, S Majee, A Samad, P Devarajan, MS Degani

Index: Kakwani, Manoj D.; Suryavanshi, Prashant; Ray, Muktikant; Rajan; Majee, Sharmila; Samad, Abdul; Devarajan, Padma; Degani, Mariam S. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 1997 - 1999

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Citation Number: 20

Abstract

A series of cinnamide derivatives was designed as potential antimycobacterial agents using molecular hybridization approach. The diamine moiety, a key feature of ethambutol and its other analogs, and certain structural features of cerulenin and cinnamic acid were hybridized to obtain cinnamide derivatives. The minimum inhibitory concentration (MIC) of all synthesized compounds was determined against M. tuberculosis H37Rv using ...