Coupling reactions of hindered isonitriles and hindered alkyl thioacids: Mechanistic studies

JL Stockdill, X Wu, SJ Danishefsky

Index: Stockdill, Jennifer L.; Wu, Xiangyang; Danishefsky, Samuel J. Tetrahedron Letters, 2009 , vol. 50, # 36 p. 5152 - 5155

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Citation Number: 15

Abstract

Recently, our laboratory described a novel microwave-mediated coupling reaction between carboxylic acids and isonitriles leading to the formation of N-formyl amides. 1 These N-formyl amides are readily converted to biologically important linkages such as amides, N-hydroxymethyl amides and N-methyl amides. 2 Further experimental 3 and computational 4 investigations showed that E and/or Z formimidate carboxylate mixed anhydrides (FCMAs), formed from the merger ...