In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers

…, HK Rim, HE Choi, KS Kim, M Huang, H Rhim…

Index: Jang, Sun Jeong; Choi, Heung Woo; Choi, Doo Li; Cho, Sehyeon; Rim, Hong-Kun; Choi, Hye-Eun; Kim, Ki-Sun; Huang, Minghua; Rhim, Hyewhon; Lee, Kyung-Tae; Lee, Jae Yeol Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6656 - 6662

Full Text: HTML

Citation Number: 11

Abstract

Abstract The growth inhibition of human cancer cells via T-type Ca 2+ channel blockade has been well known. Herein, a series of new 3, 4-dihydroquinazoline derivatives were synthesized via a brief SAR study on KYS05090 template and evaluated for both T-type Ca 2+ channel (Ca v 3.1) blockade and cytotoxicity on three human ovarian cancer cells (SK- OV-3, A2780 and A2780-T). Most of compounds except 6i generally exhibited more potent ...