. pi.-Substituent constants for the 2H-1, 2, 4-benzothiadiazine 1, 1-dioxide system

JG Topliss, MD Yudis

Index: Topliss,J.G.; Yudis,M.D. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 400 - 403

Full Text: HTML

Citation Number: 12

Abstract

Method. Partition coefficients, between n-octanol and water, of a series of substituted 2H-1, 2, 4-benzothiadiazine 1, I-dioxides were measured (Table I) from which n values for a variety of substituents at different positions in the nucleus were calculated (Table 111) using the relationship nX= log Px-logpH. In addition to the parent 2H-1, 2, 4-benzothiadiazine 1, I- dioxide (Table I, l), the 3-methyl, 6-