Tetrahedron

Hydroboration and Suzuki–Miyaura coupling reactions with the electronically modulated variant of an ynamine: the synthesis of (E)-β-arylenamides

B Witulski, N Buschmann, U Bergsträßer

Index: Witulski, Bernhard; Buschmann, Nicole; Bergstraesser, Uwe Tetrahedron, 2000 , vol. 56, # 43 p. 8473 - 8480

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Citation Number: 103

Abstract

The first hydroboration of an 1-alkynylamide—the electronically modulated variant of an ynamine—is described. This hydroboration in combination with a Suzuki–Miyaura cross- coupling reaction with aryl bromides or aryl iodides allows a flexible synthesis of (E)-β- arylenamides and 3-(2′-amidovinyl) indoles with high degree of molecular diversity.

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