New heterocyclic compounds from 1, 2, 4-triazole and 1, 3, 4-thiadiazole class bearing diphenylsulfone moieties. Synthesis, characterization and antimicrobial activity …

…, C Draghici, F Barbuceanu, G Bancescu

Index: Barbuceanu, Stefania-Felicia; Saramet, Gabriel; Almajan, Gabriela Laura; Draghici, Constantin; Barbuceanu, Florica; Bancescu, Gabriela European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 417 - 423

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Citation Number: 54

Abstract

Some new 5-(4-(4-X-phenylsulfonyl) phenyl)-4-(R)-2H-1, 2, 4-triazol-3 (4H)-thiones 4a, b; 5a, b and 5-(4-(4-X-phenylsulfonyl) phenyl)-N-(R)-1, 3, 4-thiadiazol-2-amines 6a, b; 7a, b were obtained by cyclization of new N1-[4-(4-X-phenylsulfonyl) benzoyl]-N4-(R)- thiosemicarbazides 2a, b; 3a, b (X= H, Br). The 1, 2, 4-triazoles were synthesized by intramolecular cyclization of acylthiosemicarbazides, in basic media. On the other hand, 1, ...

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