Chemical Communications

Facile synthesis of 4-vinyl-and 4-fluorovinyl-1, 2, 3-triazoles via bifunctional “click-olefination” reagents

R Kumar, P Pradhan, B Zajc

Index: Kumar, Rakesh; Pradhan, Padmanava; Zajc, Barbara Chemical Communications, 2011 , vol. 47, # 13 p. 3891 - 3893

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Citation Number: 18

Abstract

Modular synthesis of vinyl and fluorovinyl triazoles can be achieved from bifunctional propargyl and fluoropropargyl sulfones by Cu-catalyzed azide–alkyne ligation and Julia– Kocienski olefination. Competitive click reactions of the protio and fluoropropargyl sulfones show higher reactivity of the latter, and a preliminary DFT analysis was performed.

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