Tetrahedron Letters

Palladium-catalyzed synthesis of stereodefined 3-[(1, 1-unsymmetrically disubstituted) methylidene] isobenzofuran-1 (3H)-ones and stereodefined 5-[(1, 1- …

…, F Bellina, M Biagetti, A Catanese, L Mannina

Index: Rossi, Renzo; Bellina, Fabio; Biagetti, Matteo; Catanese, Antonella; Mannina, Luisa Tetrahedron Letters, 2000 , vol. 41, # 27 p. 5281 - 5286

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Citation Number: 74

Abstract

Treatment of (hetero) aryl halides with 2-(1-alkynyl) benzoic acids or (Z)-2-en-4-ynoic acids in the presence of K2CO3 and a catalytic amount of Pd (PPh3) 4 provides reaction mixtures in which stereodefined 3-[(1, 1-unsymetrically disubstituted) methylidene] isobenzofuran-1 (3H)-ones and stereodefined 5-[(1, 1-unsymmetrically disubstituted) methylidene] furan-2 (5H)-ones, respectively, are the major products.

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