“Molecular chameleons”. Design and synthesis of C-4-substituted imidazole fleximers

KL Seley, S Salim, L Zhang

Index: Seley, Katherine L.; Salim, Samer; Zhang, Liang Organic Letters, 2005 , vol. 7, # 1 p. 63 - 66

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Citation Number: 19

Abstract

The synthesis of two flexible nucleosides is presented. The “fleximers” feature the purine ring system split into its imidazole and pyrimidine components. This modification serves to introduce flexibility to the nucleoside while still retaining the elements essential for molecular recognition. As a result, these structurally innovative nucleosides can more readily adapt to capricious binding sites and, as such, should find use for investigating enzyme-coenzyme ...