Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222

…, G Bifulco, M Taddei, L Gomez??Paloma

Index: Rodriquez, Manuela; Terracciano, Stefania; Cini, Elena; Settembrini, Giulia; Bruno, Ines; Bifulco, Giuseppe; Taddei, Maurizio; Gomez-Paloma, Luigi Angewandte Chemie - International Edition, 2006 , vol. 45, # 3 p. 423 - 427

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Citation Number: 39

Abstract

The organization of DNA into chromatin plays a major role in gene regulation. Changes in chromatin architecture (chromatin remodeling) can be modulated by acetylation, methylation, phosphorylation, and ubiquitination of N-terminal histone tails.[1] Histone acetylation is the best-understood mechanism of chromatin remodeling, and is essentially governed by the antagonistic activity of histone acetyltransferases (HATs) and histone ...