Copper??Catalyzed Synthesis of N??Unsubstituted 1, 2, 3??Triazoles from Nonactivated Terminal Alkynes

T Jin, S Kamijo, Y Yamamoto

Index: Jin, Tienan; Kamijo, Shin; Yamamoto, Yoshinori European Journal of Organic Chemistry, 2004 , # 18 p. 3789 - 3791

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Citation Number: 85

Abstract

Abstract The [3+ 2] cycloaddition of nonactivated terminal alkynes and trimethylsilyl azide proceeded smoothly in the presence of Cu I catalyst and DMF/MeOH, to give the corresponding N-unsubstituted triazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a copper acetylide species and hydrazoic acid, followed by a successive [3+ 2] cycloaddition reaction.(© Wiley-VCH Verlag GmbH & Co. ...

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