An efficient and scalable synthesis of N-(benzyloxycarbonyl)-and N-(methyloxycarbonyl)-(S)-vinylglycinol
A Lumbroso, V Coeffard, E Le Grognec, I Beaudet…
Index: Lumbroso, Alexandre; Coeffard, Vincent; Le Grognec, Erwan; Beaudet, Isabelle; Quintard, Jean-Paul Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3226 - 3228
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Citation Number: 5
Abstract
An efficient and scalable synthesis of N-(benzyloxycarbonyl)-and N-(methyloxycarbonyl)-(S)- vinylglycinol has been reported starting from the commercially available (l)-methionine. The scale-up preparation consisted of 5 steps and delivered up to 50g of the desired N-protected β-amino alcohols in 32% and 36% overall yields.
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