Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression

JP Holland, MW Jones, S Cohrs, R Schibli…

Index: Holland, Jason P.; Jones, Michael W.; Cohrs, Susan; Schibli, Roger; Fischer, Eliane Bioorganic and Medicinal Chemistry, 2013 ,  vol. 21,  # 2  p. 496 - 507

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Citation Number: 9

Abstract

Anti-mitotic anti-cancer drugs offer a potential platform for developing new radiotracers for imaging proliferation markers associated with the mitosis-phase of the cell-cycle. One interesting target is kinesin spindle protein (KSP)—an ATP-dependent motor protein that plays a vital role in bipolar spindle formation. In this work we synthesised a range of new fluorinated-quinazolinone compounds based on the structure of the clinical candidate ...