Steric vs. electronic effects in the Lactobacillus brevis ADH-catalyzed bioreduction of ketones

…, JH Sattler, W Kroutil, I Lavandera, V Gotor

Index: Rodriguez, Cristina; Borzecka, Wioleta; Sattler, Johann H.; Kroutil, Wolfgang; Lavandera, Ivan; Gotor, Vicente Organic and Biomolecular Chemistry, 2014 ,  vol. 12,  # 4  p. 673 - 681

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Citation Number: 17

Abstract

Lactobacillus brevis ADH (LBADH) is an alcohol dehydrogenase that is commonly employed to reduce alkyl or aryl ketones usually bearing a methyl, an ethyl or a chloromethyl as a small ketone substituent to the corresponding (R)-alcohols. Herein we have tested a series of 24 acetophenone derivatives differing in their size and electronic properties for their reduction employing LBADH. After plotting the relative activity against ...