Proton NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of" enkephalinase" inhibitors. …

MC Fournié-Zaluski, E Lucas-Soroca…

Index: Fournie-Zaluski; Lucas-Soroca; Devin; Roques Journal of medicinal chemistry, 1986 ,  vol. 29,  # 5  p. 751 - 757

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Citation Number: 37

Abstract

[3-[[1 (RS)-(mercaptomethyl)-2-phenylethyl] amino]-3-oxopropanoic acid], two highly potent inhibitors of enkephalinase, a neutral endopeptidase involved in enkephalin metabolism, is reported. Due to a rapid isomerization process, derivatives of retro-thiorphan, which contains a 2-substituted malonyl moiety, cannot be separated by classical methods. However, a separation of the diastereoisomeric mixtures of these retro-thiorphan derivatives was ...