On the regioselectivity of the reaction of N-methoxycarbonylpyridinium chloride with Grignard reagents: highly regioselective synthesis of 2-substituted N- …

R Yamaguchi, Y Nakazono, M Kawanisi

Index: Yamaguchi, Ryohei; Nakazono, Yutaka; Kawanisi, Mituyosi Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1801 - 1804

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Citation Number: 77

Abstract

Abstract Whereas alkyl Grignard reagents undergo 1, 2-and 1, 4-additions to N- methoxycarbonylpyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1, 2-addition to afford 2-substituted N-methoxycarbonyl-1, 2- dihydropyridines in fair to excellent yields.