Ionic liquid mediated one-pot synthesis of 6-aminouracils

SS Chavan, MS Degani

Index: Chavan, Sunil S.; Degani, Mariam S. Green Chemistry, 2012 , vol. 14, # 2 p. 296 - 299

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Citation Number: 11

Abstract

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1, 1, 3, 3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.